Epidemiology and risk profile of heart failure. Details of the comparisons are shown in Supplemental Table 2. Two reviewers extracted the data and made the quality assessment.
Cardiovasc Drugs Ther ; Any disagreement between 2 authors was resolved by discussion. We chose the mean age as the covariate. Bach R, Zardini P.
A total of participants were included in this meta-analysis. One study included patients with preserved ejection fraction. Ejection Fraction Five studies patients with 3 drugs captopril, enalapril, and lisinopril and placebo were included. A first-choice blood pressure treatment for many people. Ir Med J ; New England Journal of Medicine A complete search strategy is listed in Supplemental File 1. Evidence synthesis for decision making 2: In terms of blinding of participants and personnel, 5 studies had a low risk of bias.
Two authors extracted first author, publication year, comparison, sample size, country, setting single center or multicenterproportion of men, age, maximum follow-up duration from included studies.
When the study only supplied a range of ages, we calculated the mean age by dividing equally the sum of the upper and lower limits; when the study supplied sex-specific ages, we calculated the mean age by using the following formula: It lowers your risk of heart attack and stroke.
Effects of captopril and enalapril on renal function in elderly patients with chronic heart failure. For missing data, we carried out an intention-to-treat analysis if possible. The model fitted the data well if posterior mean residual deviance approximated data points.
The results of the pairwise and network meta-analyses are shown in Supplemental Tables 1—9. Enalapril reduces the catecholamine response to exercise in patients with heart failure. Last, our article used summary data rather than individual patient data, which could introduce some biases at the individual patient level. This might, in part, be because so many factors in clinical settings can result in the death of a patient, and it is difficult to make a direct correlation between treatment with ACEI and a reduction in all-cause mortality.
Original Research Article First Online: Two studies did not blind to participants and personnel.