Severe intoxication with methotrexate possibly associated with concomitant use of proton pump inhibitors. Do not take more or less medicine than ordered. More recently Kurata et al.
Although conflicting data were reported in some case reports for either omeprazole or pantoprazole Whelan et al. Accepted September 19, In our study, the estimated K m value for hOAT3 was View latest questions Search for answers Ask a question. To view content sources and attributions, please refer to our editorial policy. I've icluded the link for your use: Methotrexate MTX is a widely used drug for the treatment of various malignancies, including leukemia, lymphoma, and sarcoma.
Major Highly clinically significant. In agreement with our results, Nies et al. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Other drugs that have the same active ingredients e. Unfortunately the difference from the mock cells was not sufficient to evaluate the drug-drug interaction. Over the past few years, data have appeared that indicate a potential interaction between MTX and proton pump inhibitors PPIs.
MTX is currently used in wide range of doses, and high-dose MTX schedules are associated with an incidence of nephrotoxicity of 1. Contribute Today More Ways to Give. Species-Specific Metabolism by Molybdenum Hydroxylases.
In rare cases some people may develop lung problems.
It appears that patients receiving high-dose MTX are particularly at risk for this interaction. Related support groups Support group for people who take Methotrexate Support group for people who take Zantac and Methotrexate Support group for people who take Zantac The calculated half-maximal inhibitory concentration values were in the micromolar range.
Please tell your doctor if you have a history of any alcohol abuse, hepatitis, yellow jaundice, or liver disease. Chioukh, Noel-Hudson, Ribes, Verstuyft. Different individuals may respond to medication in different ways. Antimetabolites Antipsoriatics Antirheumatics Other immunosuppressants.
The protein content of the supernatant was determined using the BCA assay. Methotrexate is a powerful medication that can be used for many serious conditions.
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