This range was established to assess digoxin toxicity, not effectiveness.
Metabolic effects of diuretics. Direct evidence from intraneural recordings for increased central sympathetic oUTFlow in patients with heart failure. A kinetic and hemodynamic study of digoxin was performed in six healthy subjects and similar studies were performed during digoxin with spironolactone and with triamterene. The study cohort comprised heart failure HF patients taking digoxin between andin whom digoxin intoxication requiring a hospitalization ICD-9 code Tolerance to intravenous nitroglycerin in patients with congestive heart failure: Racial differences in the outcome of left ventricular dysfunction.
Secondary prevention with verapamil after myocardial infarction. Subsequent investigations found that digitalis was most useful for edema that was caused by a weakened heart i. Management of acute decompensated heart failure. Neurohormonal and cytokine activation in heart failure.
Reanalysis of Digoxin Therapy for Heart Failure
It seems reasonable to initiate digoxin therapy in women only when they are clearly symptomatic despite receiving maximal treatment with more-proven agents such as diuretics e. Risk of death associated with nesiritide in patients with acutely decompensated heart failure.
Diuretic drugs and the treatment of edema: A prospective clinical study with serum level correlations. Confusion Irregular pulse Loss of appetite Nauseavomitingdiarrhea Fast heartbeat Vision changes unusualincluding blind spots, blurred vision, changes in how colors look, or seeing spots Other symptoms may include: This content is owned by the AAFP.
Examples of diuretics Thiazides diuretics Loop diuretics Potassium sparing diuretics Carbonic anhydrase inhibitors Osmotic diuretics Nonprescription diuretics. Intravenous recombinant human relaxin in compensated heart failure: Effects of BG, an adenosine A1 receptor antagonist, in patients with congestive heart failure.
The observed differential effect of each individual diuretic on the risk of digoxin intoxication can probably be attributed to their differential ability to cause electrolyte abnormalities.
Their analyses also indicated that different thiazides could result in variation in the reduction of the serum potassium concentration. Diuretic dose and long-term outcomes in elderly patients with heart failure after hospitalization. Already a member or subscriber? Acetylstrophanthidin-induced reflex inhibition of canine renal sympathetic nerve activity mediated by cardiac receptors with vagal afferents.
For patients with more than one incidence of hospitalization for digoxin intoxication, only the first hospitalization was considered for analysis.
Blood pressure and cardiac performance. Specifically, spironolactone was found to inhibit tubular secretion of digoxin, and consequently led to an increase in the serum digoxin concentration [ 41 ]. Cases and matched controls were comparable in the matching variables: Want to use this article elsewhere?