Diethyldithiocarbamate disulfiram

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Prog Liver Dis Didn't get the message? Disulfiram and Its Metabolite Diethyldithiocarbamate: MeDDC sulfine formation in renal microsomes was effectively inhibited by methimazole, a competitive inhibitor of FMO, and by heat inactivation Table 2. Cashman JR Structural and catalytic properties of the mammalian flavin-containing monooxygenase.

Supplemental Content

CYP4A11 did not catalyze this reaction at a detectable level. Disulfiram implantation in alcoholism treatment: Chem Res Toxicol 8: Acknowledgment We thank Frank Crow in the Biomedical Mass Spectrometry and Functional Proteomics department at the Mayo Clinic for providing the mass spectrometry characterization of benzydamine N -oxide. J Biol Chem Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper ties.

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We cannot rule out the possibility that CYP was preferentially degraded in our samples of kidney microsomes. Treatment of alcoholism with a sensitizing drug.

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Abstract In the present study in vitro interactions of disulfiram an agent used to induce ethanol intolerance in alcoholicsdiethyldithiocarbamate DDCand metronidazole with central benzodiazepine receptors CBR and peripheral benzodiazepine BZ receptors PBR were investigated in rat tissues. The second major metabolite of amobarbital in man. Gennett PikeDennis C.

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Unable to display preview. After sitting undisturbed for 18 h at room temperature, platinum black was added until the evolution of gas ceased.

Materials and Methods

We do not retain these email addresses. Send reprint requests to: Scatchard analysis of [3H]PK binding to kidney membranes, performed in the absence or presence of 7 x 10 -7 M disulfiram, decreased ligand affinity without influencing the maximal number of binding sites, suggesting a competitive inhibition. SW, Rochester, MN The stability of sodium diethyldithiocarbamate in biochemical experiments. Thus, based on the metabolic capacity of each organ, formation of MeDDC sulfine is probably quantitatively much less important in the kidney than it is in the liver of an otherwise healthy patient.

Benzydamine N -oxide hydrogen maleate was synthesized by oxidizing benzydamine with hydrogen peroxide Cope and Ciganek, ; Kataoka et al.