Treating sarcoidosis with methotrexate

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The common side effects of corticosteroids include:. J Occup Environ Med. Lupus pernio consists of indurated plaques and discoloration of the nose, cheeks, lips, and ears and usually indicates a chronic disease course that is unlikely to result in spontaneous remission.

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Early Treatment of stage II sarcoidosis improves 5-year pulmonary function. It is unclear if asymptomatic patients will ever need therapy, even if they have diffuse lung infiltration. Patients both male and female should be advised to use adequate birth control for up to six months after discontinuation of the drug. This site complies with the HONcode standard for trustworthy health information: What are the side effects of the other drugs? In one study of patients with rheumatoid arthritis the routine use of folate significantly reduced toxicity from methotrexate.

It is one of the more common substitutes for steroids. A recent RCT 14 of inhaled fluticasone Flovent in the treatment of chronic stable sarcoidosis showed no benefit in lung function and chest radiographs, but a positive tendency toward symptomatic relief that was not statistically significant.

Every-otherday dosing may be considered. There is no cure for sarcoidosisbut the disease may get better on its own over time.

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There appear to be four major categories of toxicity: However, it can be useful for many patients. In over patients treated we have seen three patients with possible methotrexate pulmonary toxicity.


He was diagnosed with lung sarcoid in and has been in remission for a decade Report this. J Lab Clin Med Read the full text or download the PDF: Imuran does not cause an increase in blood pressure, but it may cause renal function impairment.

Relapses were frequent after discontinuation of treatment, suggesting that methotrexate suppresses but does not cure the disease. If sarcoidosis does not disappear, it either remains stable or progresses. BHL and parenchymal infiltrates.

The decision to begin treatment generally depends on the organ system involved and the severity of disease.

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Given the above information, our approach to the use of methotrexate in patients with sarcoidosis is summarised in fig 2. Lesions can range from non-specific maculopapular eruptions, such as plaques and nodules, to erythema nodosum and lupus pernio.

Other treatments are available for patients who cannot tolerate steroids either because they are contraindicated or because side effects cannot be tolerated.